3^rd International Conference on Genetics and Molecular Biology April 18-19, 2022 Miami, USA

Molecular Microbiology & Diagnostics:

Molecular microbiology is the branch of microbiology devoted to the study of the molecular basis of the physiological processes that occur in microorganisms. Molecular diagnostics is referred to as the detection of genomic variants, aiming to facilitate detection, diagnosis, sub classification, prognosis, and monitoring response to therapy.

Cancer & Stem Cells:

Cancer begins in your cells. Normally, our body forms new cells as we need them, replacing old cells that die. The growth of extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide to produce more stem cells. They are found in multicellular organisms. In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues.

Plant genetics analysis Program awards from the National Science Foundation (NSF) that National Science Foundation offers supplements to support analysis collaboration with human sin developing countries. The intent of Developing Country Collaborations in Plant ordination analysis (DCC-PGR) awards is to support cooperative analysis linking U.S. researchers with partners from developing countries to resolve problems with mutual interest in agriculture, energy and so the environment, whereas inserting U.S. and international researchers at the center of a world network of scientific excellence.

Gene expression is the process by which the genetic code, the nucleotide sequence of a gene is used to direct protein synthesis and produce the structures of the cell. Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to specific DNA elements to regulate transcription, or mechanisms that modulate translation of mRNA.

The capability to make specific modifications to the human gene has been an objective in medical since; gene is the recognition of the basic unit for heredity. Therefore, gene therapy is defined as the capability of genetic improvement through the correction of modified genes or specific modifications that target therapeutic treatment. This therapy became possible through the advances of genetics and bioengineering that enabled manipulating vectors for delivery of extra chromosomal material to target cells. One of the major focuses on this technique is the optimization of delivery vehicles (vectors) that are mostly plasmas, unstructured or viruses. These viruses are more often investigated due to their excellence of infected cells and inserting their genetic material

In recent years, stem cell nanotechnology has emerged as a replacement of exciting field. Experimental and Theoretical studies of interaction between nanostructures or nanomaterial’s and stem cells have created nice advances. The importance of nanotechnology, nanostructures, and nanomaterial’s to the elemental developments in stem cells-based therapies for injuries and degenerative diseases has been recognized. In general, the consequences of properties and structure of nanomaterials on the accretion and differentiation of stem cells became a replacement of integrative border in reconstruction medicine and material science

• Nanoparticles: Cell Tracking, And Endocytosis
• Nano vaccines
• Nanomaterial’s And Nano engineering
• Nanotechnology For Genetic Engineering
• Nanotechnology For Creating Stem Cell Niche
• Nanoparticle Toxicity To Stem Cells

The skin gradually re-establishes itself for the duration of grown-up life, and the hair follicle experiences a never ending cycle of development and decay. Microorganisms (Stem Cell’s) lives in the epidermis and hair follicle guarantee the support of grown-up skin equilibrium and hair recovery; however they likewise take part in the fix of the epidermis after wounds.

• Stem Cells With In Adult Skin Epithelium


• Signalling And Stem Cell Fate Specification In The Skin


• Bone Morphogenetic Protein Signalling


• Notch Signalling

The number of individuals with chronicle wounds has been increasing worldwide due to a fading population, diabetes, obesity, and cardiovascular disease. In the U.S, almost seven million people have chronic skin ulcers. Many restorative approaches have been used. Whatever, the treatment comes out  are not always ideal because of failure to achieve complete wound closure in around 60% of cases, scarring, and high rate of recurrence. However, there is a need of more effective therapies. Stem cells offer promising possibilities. Pre-clinical studies have shown that bone- or adipose tissue-derived mesenchyme stem cells (MSCs) have a competitive advantage over other types of stem cells due to their better defined multi potent differentiating potential, paracrine effects, immune modulatory properties, and safety. Therefore, large controlled clinical trials are needed to examine the capabilities of MSCs in humans and to assess their safety profile. In this review, we highlight emerging treatments in tissue regeneration and repair and provide some perspectives on how to translate current knowledge about stem cells-both multi potent and pluripotent-into the clinical approach for treating patients on heal wounds

• Novel Stem Cell Therapy For Knees


• Novel Stem Cell Therapy For Arthritis


• Novel Stem Cell Therapy For Cancer


• Novel Stem Cell Therapy For Hair loss

Cell therapy (also called cellular transplantation, cell therapy, or cytotherapy) is a therapy in which possible cells are injected, implant or embed into a patient in order to effectuate a medicinal effect, for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stem cells to regenerate diseased tissues.

Cell therapy commenced in the nineteenth century when scientists experimented by injecting animal material in a try to prevent and treat illness. However, such try didn’t produced any  positive benefit, the next research was  found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation has become common practice in treatment for patients that have compromised bone marrow after disease, infection, radiation or chemotherapy. 

• Allogeneic Cell Therapy


• Autologous Cell Therapy


• Xenogeneic Cell Therapy

The capability to make specific modifications to the human gene has been an objective in medical since; gene is the recognition of the basic unit for heredity. Therefore, gene therapy is defined as the capability of genetic improvement through the correction of modified genes or specific modifications that target therapeutic treatment. This therapy became possible through the advances of genetics and bioengineering that enabled manipulating vectors for delivery of extra chromosomal material to target cells. One of the major focuses on this technique is the optimization of delivery vehicles (vectors) that are mostly plasmas, unstructured or viruses. These viruses are more often investigated due to their excellence of infected cells and inserting their genetic material.

• Substitution of the adenosine deaminize deficiency


• Substitution of α 1-antitrypsin


• Improvement of immune function


• Tumour removal


• Chemo protection


• Enzymatic substitution


• Cytokine release

Immunotherapy is considered as a type of cancer treatment that helps your immune system to fight against cancer. The immune system helps your body to fight with infections and other diseases. It is consists of organs and white blood cells and tissues of the lymph system.

Immunotherapy is a type of biological therapy. Organic therapy is a type of treatment that we use from the substances made from living organisms to treat cancer.

• Immune checkpoint inhibitors


• T-cell transfer therapy


• Monoclonal antibodies


• Immune system modulators

There are many types of cancer treatment. Which types of treatment that you can prescribe will depend on the type of cancer that you have and how advanced it is. Some people who were facing with cancer will have only one treatment. But most people have a rear case in combination of treatments, such as surgery with chemotherapy and also with radiation therapy. When you need a treatment for cancer, you have a lot to think and learn about. It is normal to feel affected and confused. But, talking with your doctor and learning about which type of treatment you may have can help you feel better and can control the fear.

• Surgery


• Radiation Therapy


• Chemotherapy


• Immunotherapy


• Targeted Therapy


• Hormone Therapy


• Stem Cell Transplant

Precision Medicine

At the present scenario   Cancer therapies are not basing on surgery, radiation, and chemotherapy. Because all these three methods cause a risk damage to normal tissues or incomplete destruction of the cancer. Nano- therapy means to target chemotherapies and also collectively to cancerous cells and neoplasms, guide in surgical resection of tumour and enhance the therapeutic competence of radiation-based and the other current based treatment methods. All these together can decrease the risk to the patient and an increased probability of survival.

• Delivering Chemotherapy
• Nano-enabled Immunotherapy
• Delivering or Augmenting Radiotherapy
• Delivering Gene Therapy

Epigenetics is rising to eminence in biology as a mechanism by which environmental factors have intermediate-term effects on gene expression without changing the underlying genetic sequence. It can occur through the specific methylation of DNA bases and modification of histones. There are wide-feeding implications for the gene-environment contest and epigenetic mechanisms are causing a revaluation of many traditional concepts such as heritability. The reversible nature of epigenetics also provides conceivable treatment or prevention prospects for diseases previously thought hard-coded into the gene. Therefore, we consider how growing knowledge of epigenetics is altering our understanding of biology and medicine, and its implications for future research.

• Covalent modifications


• RNA transcripts


• MicroRNAs


• mRNA


• sRNAs


• Prions


• Structural inheritance


• Nucleosome positioning


• Genomic architecture