Farah Ibrahim Al-Marzooq
Research Institute of Medical & Health Sciences, University of Sharjah, UAE
Title: The oral microbiome and salivary biomarkers in health and disease
Biography
Biography: Farah Ibrahim Al-Marzooq
Abstract
The oral microbiome plays a relevant role in human health and it is a key element in a variety of oral and systemic diseases.Th ere is a relation between oral and systemic diseases, but the question remains whether the oral diseases are the causeor theconsequence of pathological process in other body sites. We aim to compare the bacterial community and the level ofselected biomarkers in the saliva of adults in health and disease conditions. 90 saliva samples were collected from three equalgroups (obese with diabetes, obese without diabetes and healthy control). Resistin (a biomarker of insulin resistance) was measured in saliva using ELISA technique. Real-time PCR was used to quantify selected bacterial species associated with ora linfections. Salivary resistin was signifi cantly higher in the obese patients (diabetics and non-diabetics) compared to the healthycontrol. Fusobacterium (associated with gingivitis), Porphyromonas gingivalis and Tannerella forsythia (associated withperiodontitis) were detected in signifi cantly higher quantities in the obese patients (diabetics and non-diabetics) comparedto the healthy control. No correlation was found between the levels of salivary resistin and diff erent oral bacteria. Th is study highlighted the importance of saliva as a non-invasive sample for the detection of biomarkers and microbes associated with oral and systemic diseases. Th is may pave the way for more eff ective diagnostic and therapeutic methods which can contributeto the development of personalized medicine and personalized dental medicine.