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Lin Zhi-Xiu

Lin Zhi-Xiu

The Chinese University of Hong Kong, Hong Kong

Title: Isorhynchophylline improves learning and memory impairments induced by aluminum chloride in mice

Biography

Biography: Lin Zhi-Xiu

Abstract

Isorhynchophylline (IRN), an alkaloid isolated from Uncaria rhynchophylla, has been reported to improve cognitive impairment induced by beta-amyloid in rats. However, whether IRN could also ameliorate the aluminum chloride (AlCl3)-induced mouse memory deficits is still not clear. In the present study, we aimed to investigate whether IRN had potential protective effect against the AlCl3-induced cognitive deficits in mice. Mice were given a subcutaneous injection of AlCl3 (50 mg/kg) and orally administered IRN (20 or 40 mg/kg) daily for 8 weeks, followed by assessing spatial learning and memory function by the Radial Arm Maze test. The results showed that IRN significantly improved spatial learning and memory function in the AlCl3-treated mice. In the mechanistic studies, IRN significantly increased the level of glutathione (GSH) and the activities of superoxide dismutase (SOD) and catalase (CAT), while decreased the level of malondialdehyde (MDA) in the brain tissues of the AlCl3-treated mice. Moreover, IRN (40 mg/kg) significantly inhibited/decreased the acetylcholinesterase activity, as well as the activation of nuclear factor kappa B (NF-ĸB) in the brain tissues of AlCl3-treated mice. These results indicate that IRN was able to ameliorate cognitive deficits induced by AlCl3 in mice, and the observed actions may be mediated, at least in part, by the inhibition of acetylcholinesterase activity and the enhancement of the antioxidant status of brain tissue.

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