Pharmacogenetics

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Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses towords the drugs, both in their terms of therapeutic effect as well as adverse effects. In oncology, pharmacogenetics historically is the study of germ line mutations (e.g., single-nucleotide polymorphisms affecting genes coding for liver enzymes responsible for drug deposition and pharmacokinetics), whereas pharmacogenomics refers to somatic mutations in tumoral DNA leading to alteration in drug response. 

  • a. Translational Pharmacogenomics b. Cancer Pharmacogenomics c. Pharmacogenitics & Individualized therapy

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